DHHS/PHS/FDA/Office Of Facilities, Acquisition, And Central Services, Division of Contracts and Program Management, HFA-512(COB), 5600 Fishers Lane, Rockville, MD 20857

66 -- CONSOLE UPGRADE FOR AMX 500 NMR SPECTROMETER SOL A62453-00-99 DUE 092799 POC Paul Scarborough, Contracting Officer, (301) 827-7168 The Food and Drug Administration intends to purchase a Bruker Avance 500 Console or equal. The console upgrade is to replace a current Bruker AMX500 and will interface seamlessly with the probes, and current computer (SGI) in use. The upgraded spectrometer will be integrated with the existing 300 MHz spectrometer so that the lab will use a standard set of pulse programs and parameters. It is crucial that both the 500 MHz and 300MHz be nearly identical so that the scientists can use the same pulse programs and parameters on both NMR spectrometers. The console upgrade shall include the following: at least a 28 shim system; a new upper shim stack, which enables high flow rates for VT gases; a digital lock control unit with digital lock freqency generation, a digital lock frequency generator, fast field adjustments, a microprocessor-controlled lock regulation system with low noise, high-precision shim control boards; a double-width 19" rack mounted, fr shielded cabinet; on 100 Watt 1H/19F linear array amplifier for 1H/19F pulse and homo/heteronuclear 1H/19 decoupling (100 Watt pulse and 25 Watt cw power; 8 Watt linear and 0.8 Watt ultra linear stages, all operations undr computer control with total dynamic excitation range greater than 120dB); three linear broadband amplifiers for X-nucleus pulse and decouple with ultra-fast blankingand rise/fall times (300 Watt pulse power, up to 30 Watt linear cw, all operations under computer control); multilink preamplifier, including 1H, 2H, and BB preamplifiers, Control unit and built-in tune and match display; quadrature detection receiving with an intermediate frequency of 451MHz; a router for automated high-speed configuration of rf signals; a deuterium lock switch for deuterium decoupling and lock switching; communication control unit with 100 MHz RISC microprocessor 16MB buffer memory, a dedicated ethernet link (10Mbit/sec); a timing control unit, with ultra-fast VME pulse programmer to achieve timing with 12.5 ns resolution; five frequency control units for generation of phase amplitude and frequency, which use direct digital synthesis, and have a phase settability of 0.05 degrees and a frequency resolution of 0.001 Hz, as well as an amplitude shaping unit; a gradient control unit interfaced to the VME bus for simultaneous control of three magnetic field gradient channesl with real-time generation of gradient shapes; a receiver control unit interfaced to the VME bus for acquisition of NMR data with oversampling and digital filtering, providing greater than 18-bit effective dynamic range; a receiver upgrade to DQD; a gradient amplifier upgrade to one which is fully and seamlessly interfaced with a digital NMR system and where the preemphasis is adjustable by software; a variable control unit with accuracy of 0.01 degree C; a precooling and stabilizing accessory for ultra-precise temperature control; two tuitions to training courses, a complete set of system documentation; a complete installation by qualified personnel, to be completed in the purchaser's lab within 10 business days of dismantling the old console, which shall be not longer than 8 months after the order of the console is placed. The new console shall meet specs equivalent to those met by the most recently installed Avance spectrometers in the Structural Biophysics Laboratory, NHLBI, NIH, except that the pulse droop on spin-lock pulses will be no greater than 3%, and the probe lineshape, linewidth, and sensitivity specs for the triple resonance three axis gradient probe will be matched to specs the time of delivery of that probe. Payment terms will be 20% upon delivery and 80% upon demonstration of specs in the users lab. This procurement is being awarded in accordance with FAR Subpart 13.5. Written quotes due to this office 2:00 pm, 9/27/99. Posted 09/16/99 (W-SN381025). (0259)

Loren Data Corp. http://www.ld.com (SYN# 0196 19990920\66-0001.SOL)